Oncology Nurse Advisor Feb 7, 2013
“Gold nanoparticles kill lymphoma without chemotherapy”
by Kathy Boltz PhD
Lymphoma can be starved to death by depriving it of what appears to be a favorite food: high-density lipoprotein (HDL) cholesterol.
A new nanoparticle appears to the cancerous lymphoma cell like a preferred meal of natural HDL. When the particle engages the cell, it plugs it up and blocks cholesterol from entering. Deprived of an essential nutrient, the cell eventually dies.
B-cell lymphoma is dependent on the uptake of natural HDL, from which it derives fat content, such as cholesterol.
The nanoparticle, which was originally developed as a possible therapy for heart disease, closely mimics the size, shape, and surface chemistry of natural HDL particles. Its key difference is a 5-nm gold particle at its core. When the nanoparticle is incubated with human B-cell lymphoma cells or used to treat a mouse with a human tumor, the spongy surface of the gold particle sucks the cholesterol out of the cell, and the gold core prevents the cell from absorbing more cholesterol that is typically carried in the core of natural HDL particles.
Natural HDL does not kill the cells or inhibit tumor growth. The nanoparticle is essential to starve the lymphoma cell.
C.Shad Thaxton, MD, of Northwestern Medicine, the original developer of the HDL nanoparticle, gave a lecture that was attended by Leo I. Gordon, MD, also of Northwestern. Gordon knew that patients with advanced forms of B-cell lymphoma sometimes have diminishing levels of cholesterol, and he was looking for new ways to deliver drugs to patients. He contacted Thaxton, and they began the collaboration that led to this publication in Proceedings of the National Academy of Sciences.
They tested the HDL nanoparticle alone and the HDL nanoparticle transporting cancer drugs. Surprisingly, the nanoparticle without drugs was just as effective at killing the B-cell lymphoma cells.
“We thought, “’That’s odd. Why don’t we need the drug?’” Gordon recalled.
That’s when the scientists began delving into the mechanism by which the HDL nanoparticles were sticking to the HDL receptors on the lymphoma cell and manipulating cholesterol transport. In addition, patient samples analyzed by collaborators at Duke University for the study showed that lymphoma cells in patients had an overproduction of these HDL receptors compared to normal lymphocytes.
Thaxton and Gordon are encouraged by their early data showing that the HDL nanoparticles do not appear toxic to other human cells normally targeted by HDLs, normal human lymphocytes, or to mice. Also, because gold nanoparticles can be made in discreet sizes and shapes, they are excellent scaffolds for creating synthetic HDLs that closely mimic those found in nature.
“Gold has a good track record of being compatible with biologic systems,” Thaxton said, and added, “Like every new drug candidate, the HDL nanoparticle will need to undergo further testing.”
[end of article]
Wow. Interesting stuff about HDL cholesterol feeding lymphoma right?
The main reason I shared this because it’s a perfect example of published peer-reviewed research on what appears to be an effective alternative treatment for lymphoma, that will probably never be put into practice… I’m speculating of course.
But this kind of promising research is continually being published and then subsequently ignored.
Because the average drug costs 4 Billion Dollars to get FDA approval.
That is why cancer research on nutrition, natural therapies, and patent-free compounds like DCA for example, are ignored.
So next time you hear someone (usually a doctor) say, “If there was a treatment that worked better than chemo, we’d be using it.”
Don’t believe that.
Ok so I know an article like this seems like kind of a tease, because this method is not approved for use on humans. My original plan was to use it to make a point about research being ignored, but just as I was about to finish this post something was nagging at me about gold nanoparticles…
What exactly are gold nanoparticles? Where have I heard that before?
Oh yeah, it’s Colloidal Gold!
Just like colloidal silver, colloidal gold is a non-toxic mineral supplement you can buy and use!
Gold has a long history in medicine and is reported to have many therapeutic benefits from improved IQ, to arthritis, to chemical imbalances, to pain relief and more. There are literally 983 studies related just to gold nanoparticles and cancer on PubMed as of today.
Soooooo will this help you? I don’t know.
But if I had cancer again, especially lymphoma, I would be definitely be taking colloidal gold.
It may help and it certainly won’t hurt…. unless your allergic to gold.
Don’t take this if you are allergic to gold.
A normal adult dosage is 1 tbsp per day on an empty stomach, but some “super users” take as much as 8 tbsp per day.
The brand I would buy is Purest Colloids “MesoGold” because it’s 0.9999 pure colloidal gold, not ionic gold, at a concentration of 20ppm. Also MesoGold nanoparticles are 3.2 nanometers in diameter on average, which is small enough to enter the cell.